Utility of serum creatinine/cystatin C ratio in diagnosis of postrenal acute kidney injury
Author(s):
Abstract:
Background
In obstructive uropathy, despite a severe increase in the serum creatinine (Cr) levels, only a mild cystatin C (CysC) increase was previously reported. Therefore, we aimed to determine the availability of serum Cr/CysC ratio in predicting postrenal acute kidney injury (AKI). Materials And Methods
This was a cross-sectional study involving 61-adult patients with heterogeneous AKI cases. Patients with bilateral pelvicalyceal dilatation in renal sonography were considered as postrenal AKI group (n = 15) and others were intrinsic AKI group (n = 46). Venous blood sampling for blood urea nitrogen, Cr and CysC measurements were performed on admission. Results
The mean age of study population was 66.3 ± 15.5 years; 38 (62%) of which were male. Two groups were similar regarding age, gender, and comorbidities. Cr/CysC ratio was significantly higher in postrenal AKI group (6.9 ± 3.1 vs. 4.4 ± 2.1, P =0.007). Conclusion
We suggest that serum Cr/CysC ratio seems to be a useful diagnostic tool for detection of postrenal AKI cases,especially for the cases without definite hydronephrosis.Language:
English
Published:
Journal of Research in Medical Sciences, Volume:19 Issue: 11, Nov 2014
Page:
1086
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