Acemetacin and Indomethacin Detection using Modified Carbon Microelectrodes

In the present work, mercury thin film modified carbon microelectrodes were tested towards detection of the pharmacological compounds acemetacin and indomethacin. The compounds were characterized electrochemically by adsorptive stripping differential pulse and square wave voltammetry (AdSDPV and AdSSWV). Best results were obtained via AdSDPV for both compounds (Acemetacin: LOD=1.05×10-7 M, LOQ=3.51×10-7 M; Indomethacin: LOD=1.34×10-7 M, LOQ=4.47×10-7 M). These results are comparable to earlier reports using classical hanging drop mercury electrodes, but with environmental advantages due to the limited mercury amount that is used and the easy way to recover it. Detection and quantification limits are lower than the obtained with currently used analytical techniques.