Rapid Differential Pulse Voltammetric Determination of Galantamine on the Simple Glassy Carbon Electrode; Alternative for the Standard Methods

The electrochemical behavior of Galantamine (Gal) in aqueous media has been examined by cyclic and differential pulse voltammetry. The voltammograms were recorded with μA utolab FRA2 Potentiostat-Galvanostat. A three-electrode system was used with a glassy carbon as working electrode, a platinum rod as the counter electrode and an Ag/AgCl as the reference electrode. All tests were carried out under room temperature and N2 atmosphere. The pH strongly affects the peak potential of Gal. The best analytical response was obtained at pH 2.0. The cathodic peak currents were proportional to Gal concentrations in the range of 0.1–10 mM under the optimized experimental conditions. The detection limit was 0.02 mM. The effect of potential scan rate on the peak potential and peak current of Gal was investigated. The correlation of the peak currents against v1/2 (v is the scan rate) is linear, which is very similar to a diffusioncontrolled process. Proposed method applied to analysis of commercial tablets, successfully.