Potentiometric Method for the Determination of Lamivudine and Dothiepin Hydrochloride in Pharmaceutical Preparations

A simple and accurate potentiometric titration method for the determination of lamivudine and dothiepin hydrochloride is developed. For this purpose, two N bromoimides, viz., N-bromosuccinimide (NBS) and N-bromophthalimide (NBP) were used as titrants for determination of the two drugs in acid medium and the end point is determined using a platinum indicator electrode. The method was successfully applied for the determination of two drugs in their pure state or pharmaceutical preparations with mean recovery values of 99.67-100.10 and 99.55-100.33% and relative standard deviations (RSD) were 0.16-0.38 and 0.29-0.58% for lamivudine and dothiepin hydrochloride, respectively. Statistical comparison of the results with official and reported methods showed excellent agreement.