Voltammetric Determination of Paracetamol with Poly(3,4-Ethylenedioxythiophene) Modified Glassy Carbon Electrode

This study describes the preparation and application of a poly (3,4- ethylenedioxythiophene) (PEDOT) modified glassy carbon electrode for paracetamol determination in pharmaceutical samples. The PEDOT modified electrode was prepared by electropolymerizing 3,4-ethylenedioxythiophene (EDOT) on a glassy carbon electrode in a non-aqueous medium. The best performance of the PEDOT modified electrode in 0. mol L-1 phosphate buffer obtained at pH 7.0. Under these conditions, an oxidation potential of paracetamol was observed at 0.37 V versus Ag/AgCl/sat’d KCl. The cyclic voltammetric study indicates that the PEDOT modified electrode shows a very good electrocatalytic activity by reducing the overpotential by 200 mV for paracetamol oxidation. The modified electrode showed a linear response range between 2.5 and 150 μmol L-1, a sensitivity of 90.03 A/mmol L-1, quantification and detection limits of 2.5 μmol L-1 and 1.13 μmol L-1, respectively. Finally, the proposed method was applied for paracetamol determination in commercial tablets with a mean recovery of (1016) %.