Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis

For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins. No evidence of association was detected. There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.