The Synthesis of 4-(2H-Tetrazole-5-yl) Pyridine

Tetrazole functionary is a popular substation for the carboxylic acid group in the drug research field. The drug molecules containing tetrazole group have a long half time in living organism. In addition, four nitrogen atoms of tetrazole offer a greater opportunity in hydrogen bond doner acceptor interactions. In this research work, we described synthesis of new compounds of these families. Using isonicotin aldehyde and hydroxylaminehydrochloride in the pyridine, solvent was converted to 4-pyridine carbaldehyde oxime (compound 1). Then water absorption process with anhydride acetic. Organize isonicotin nitrile (2). The 4-(2H tetrazole-5-yl) pyridine (compound 3) was synthesized by [3+2] cyclo addition reaction between compound 2 and NaN3, NH4Cl, DMF at 110oC. The structures of all synthesized compounds were investigated by FT-IR and 1H NMR spectroscopes.