Synthesize (3- (3-Nitro Phenyl) - 5 Isoxazole -yl) Methanol

Message:
Abstract:
One of the most important derivatives of heteroaromatic compounds Isoxazole properties and numerous applications, including applications in pharmaceutical, agricultural, industrial and biological properties are. Isoxazole have attracted much attention in the pharmacy and the impact of these compounds in the treatment of Parkinson's and Alzheimer's disease has been proved. 3 compounds are synthesized in the present research work. By hydroxyl amine hydrochloride in the presence and in the first Bans Aldehyde solvent pyridine to form viscous liquid (compound 1) was converted. Then with sodium hypochlorite to the Nytryl Oxide become oxidized and the process, the creation [2 + 3] was performed using properly alcohol liquid mixture of isomers of 3 - phenyl Isoxazole- 5 – yl methanol and 4- Isoxazole phenyl-5-yl methanol was obtained. The addition of nitric acid at a temperature of zero degrees Celsius on Sulfuric acid composition (2), (3-(3 nytrofinil) Isoxazole- 5-yl) methanol (compound3) was obtained. Structure of the synthesized compounds by FT-IR and 1HNMR spectroscopy has been approved.
Language:
Persian
Published:
A Quarterly Publication The Application of Chemistry in Environment, Volume:2 Issue: 7, 2011
Pages:
1 to 7
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