A Survey on Zinc Status among Chronic Allergic Asthma and in Atopic Phenotype

Incidence of allergic asthma has increased in the worldwide. Zinc has significant effects on the pathogenesis of bronchial asthma. However, Zinc deficiency caused the enhanced allergy state. Investigations on the recent issue have been less often considered, and only a few studies were found in the literature review. Zinc status particularly has not been known in adult''s allergic asthma. The aim of the study was to assess the sera level of zinc in chronic allergic asthma patient with atopic phenotype. A total 48 chronic allergic asthma phenotype enrolled among asthmatic population based on the protocol. Skin prick test was applied with six standard extract allergens. Total Immunoglobulin E antibodies and zinc level were measured in sera with the recommendation manufacturer. The mean age was 32.75±9.86 SD years. Gender distribution was 52% females and 48% males. Mean of total IgE and zinc levels in sera was higher in males than females. 27% of participants had hypozincemia. Hypozincemia subset had a higher mean of total IgE level than a normal zinc level subset. Atopic phenotype was detected in 21% target population. Atopic asthmatic phenotype disclosed hypozincemia status with frequency 23%. Marked differences were observed between zinc and total IgE levels (p=0.04). The outcome disclosed there was a hypozincemia in the target population and atopic phenotype subset. Hypozincemic allergic asthmatic patients had a higher mean of total IgE level than normal Zinc level subjects. Allergic marker and hypozincemia were marked in the male and female focus population, respectively.