Effect of alcoholic extract of Iranian red onion on diabetic neuropathic pain in streptozotocin-diabetic rats
Author(s):
Abstract:
Introduction
Neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. The role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed، and extract of onion contains significant amounts of these compounds. The aim of this study was to investigate the effect of alcoholic extract of onion on diabetic neuropathic pain in streptozotocin-diabetic rats. Methods
In this experimental study، 40 male Wistar rats were divided into 5 groups: normal control، diabetic control and groups receiving alcoholic extract of onion (125، 250 and 500 mg/kg/day). After injection of streptozotocin (55 mg/kg)، the extract was administered for 3 weeks. At days 0، 7، 14 and 21 after injection of streptozotocin، assessment of neuropathic pain was performed by thermal allodynia، mechanical allodynia، hyperalgesia and formalin test. Results
Behavioral responses to thermal and mechanical stimuli in diabetic control rats showed significant reduction (P<0. 05). Oral administration of alcoholic extract of onion at doses of 125 and 250 led to improvement in diabetic neuropathic pain in all 4 tests. However، dose of 500 mg didn’t improve neuropathic pain. Conclusion
Oral administration of alcoholic extract of Iranian red onion improves diabetic neuropathic pain in rats.Keywords:
Language:
Persian
Published:
Physiology and Pharmacology, Volume:18 Issue: 4, 2014
Pages:
466 to 476
magiran.com/p1385829
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!