A Novel 1H-MRS Quantification Approach Based on Spectral Fitting for Lateralization/Localization of Seizure Foci in Patients with Temporal Lobe Epilepsy

Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasivemethod with the capability to correctly lateralize the seizure foci in patients withTemporal Lobe Epilepsy (TLE), with the first evidence published in 1993. Onemajor drawback of this modality is that the MRS data is naturally high dimensional.This, along with the time-consuming post-processing and quantificationprocedures such as spectral fitting, have made MRS impractical for clinical use.Dimension reduction techniques eliminate undesired properties of high-dimensionalspaces, suggesting simple and feasible analysis techniques in comparisonwith quantification procedures. In this study, we use two dimension reduction techniques so-called Isomapand Diffusion maps to quantify MRS data obtained from TLE patients for localizationseizure foci. Then, we evaluate the results by comparison with obtainedratio of NAA/ (Cr+Cho) from the quantification method. Our results show that the proposed methodology has the ability to localizeand/or to lateralize the seizure foci in such patients, while itmaintains minimal requiredamount of computations and time (Sensitivity=60%, Specificity=82.81%). We are hoping that this method broadens new horizons to explore theinformative yetcomplicated MRS modality into Epileptic diagnosis.