The interaction effects of aerobic training and Saffron extracts consumption on anti-oxidant defense system of heart and brain premotor cortex of young male rats following an acute bout of exhaustive endurance exercise

The present study aims to investigate the interaction effects of aerobic training and Saffron extracts consumption on anti-oxidant defense system of heart and brain premotor cortex of young male rats following an acute bout of exhaustive endurance exercise. Sixty four Rats with an age of 3 moons (weight 212±26 gr) were assigned to four equal subgroups: 1-CW; Distilled water received. 2- CSW; aqueous saffron extract received; 3- ETW; Distilled water + training. 4- ETSW; aqueous saffron extract + training. The Rats in an aerobic training group ran on a treadmill (60 min /day، 5 days/wk at 25m/min in 10% Incline) for 5 consecutive days a week. Control group did not exercise. At the end of the study period، half of each subgroup immediately before، and remained rats were killed immediately after exhaustive and measured manually، the activities of superoxide dismutase، catalase، glutathione peroxidase، and malondialdehyde and protein concentration levels of heart and brain premotor cortex. The data were analyzed by two and one-way repeated ANOVA، Showed that Lipid peroxidation levels، in the heart (subgroups 1‚3) and brain premotor cortex (subgroups 1‚2،3) tissues were significantly increased due to exhaustive. The interactive effect between exercise and Saffron extracts (subgroups 3) prevented the increased lipid peroxidation level due to exhaustive. Results of the study indicate that interaction of aerobic training and Saffron extracts can reduce the lipid peroxidation level، in the heart and brain premotor cortex tissues due to exhaustive exercise.