In Vivo Antinociceptive Effects of Persian Shallot (Allium hirtifolium) in Male Rat

The tendency toward using herbal plants instead of synthetic drugs is increasing in recent years because of their lower adverse effects and high varieties of efficient components. In this investigation, analgesic effects of hydroalcoholic leaf extract of Allium hirtifolium were studied in male rats. A total of 48 adult male rats were divided eight groups: control, intraperitoneal 50, 100, and 200 mg/kg of extract, 200 mg/kg of A. hirtifolium extract plus aspirin, aspirin (1 mg/kg), morphine (1 mg/kg), and 200 mg/kg of A. hirtifolium extract plus naloxone (1 mg/kg). The analgesic effects of A. hirtifolium were assessed with writhing, tail-flick, and formalin tests. The data were compared with control by one-way ANOVA and Tukey post hoc test. Allium hirtifolium extract at (200 mg/kg dosage), alone and in combination with aspirin, had shown antinociceptive effect in writhing, tail-flick, and formalin tests (P < 0.01). Allium hirtifolium extract (at 100 mg/kg dosage) had just shown analgesic effects on tail-flick and formalin (chronic phase) tests. It looks that A. hirtifolium has antinociceptive effects that might be due to flavonoids and saponins in plant the analgesic effect of which was demonstrated previously.