Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation

Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured. Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p) Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes.