Carbon Paste Sensor for the Determination of an Anticancer Drug Paclitaxel in Pharmaceuticals and Biological Fluids

A sensitive determination of paclitaxel (PAC) at physiological pH was developed by carbon paste electrode using cyclic, linear sweep and differential pulse voltammetric techniques. The voltammetric response of paclitaxel was excellent with carbon paste electrode at sweep rate of 50 mV/s in the potential range from 0.8 V to 1.4 V. The voltammogram of paclitaxel was irreversible. The effect of scan rate showed that the electrode process was diffusion controlled. The concentration and pH effects on the voltammogram of paclitaxel were studied. Under optimized conditions, the concentration range and detection limit were 2.0×10−6 to 2.0×10−5 M and 4.6×10−9 M, respectively. The analytical performance of this electrode was evaluated for the detection of paclitaxel in pharmaceutical and real samples.