Study of regulatory promoter polymorphism (-248 G>A) of Bax gene in patients with gastric cancer in the northern provinces of Iran
Author(s):
Abstract:
Aim
The aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer. Background
Gastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of Bcl2 lead to cancer. Patients and Methods
Blood samples were collected from 100 cases and 89 controls in the northern provinces of Iran to evaluate promoter polymorphism (-248GResultsConclusion
Allele G was the most frequent between both patient and control samples. Polymorphism may be effective on Bax expression, but it requires further investigation. Our results showed significant effects between genotypes and features of gender and age, whereas no significant relation were observed between the genotypes and grade, stage as well as smoking traits.Keywords:
Promoter , Bax gene , Gastric cancer , Polymorphism , PCR , RFLP
Language:
English
Published:
Gastroenterology and Hepatology From Bed to Bench Journal, Volume:9 Issue: 1, Winter 2016
Pages:
36 to 44
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