Effects of different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise

The aim of this study was to investigate the effects of consuming different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise in. Fifteen healthy young men (mean ± SD; age 27.0 ± 8 years; weight 73.9 ± 6 kg and height 175.3 ± 4 cm) with at least 3 years’ experience of regular participation in running or martial had voluntarily participated in this study. Subjects took different dosages of garlic (500, 750 and 1000 mg) and starch (placebo), in four separate sessions in a form of capsul with one week between them. In each session, 4 hours after taking the capsul subjects performed 30 min of running on the treadmill. Before and 4 hours after taking the capsuls and immediately after exercise hemodynamic factors and blood samples were taken. Blood samples were analyzed for blood and plasma viscosity, fibrinogen, hematocrit, hemoglobin and red blood cells (RBC) count. Data were analyzed using the repeated measures of ANOVA with repeated measure. Data analysis revealed that garlic dosage had significant effect on the plasma viscosity and fibrinogen (p=0.001). Paired comparisons showed that decreases in these two factors were significantly higher in 500 mg dosage than the two other. However, dosage of garlic did not have any significant effect on the responses of blood viscosity, hematocrit, hemoglobin and red blood cells (P=0.067). Regardless of the dosage, consuming the garlic supplement acutly 4 hours before exercise resulted in reduction in resting level of hemorheological variables (P=0.000). In addition, consuming garlic and its dosage did not have any significant effect on responses hemorheological variables to endurance exercise (P=0.59). Based on the findings of the present study, it could be concluded that consuming the garlic supplement had improved all hemorheological factors, while low dosage of garlic improves plasma viscosity and fibrinogen during exercise. So it is possible, consuming low dosage dosage (500 mg) of garlic before exercise by people with problem of hemeostasis, reduse cardiovascular risk during exercise.