A Mini Review on Modulation of MiR-155 Expression in Different Cancer Diseases

MiRNAs are a new class of small RNAs which regulate gene expression. They are supposed to be involved in a variety of cellular functions. Although, the primary targets for miRNAs are located at the 3′UTR of the genes, there are compelling evidences that miRNAs may also bind to the regions in the coding sequence of target genes. Mostly, deregulations in the miRNAs expression lead to the progress of enormous cancers. Hence, they could serve as valid biomarkers for diagnosis of cancer stages. MiR-155 has been recently interested by a variety of laboratories. MiR-155 is proposed to function as an “oncomiR”. Numerous studies have reported significantly up-regulation of this miRNA in a variety of cancers. This review describes the gene structure and molecular role of miR-155 in several cancers. Therefore targeting of this miRNA is considered as one of therapeutic solution for preventing the cancer progress.