Diosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat

Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats.
Male Wistar rats (n = 28) were divided into equal-sized control, diosgenin-treated control, diabetic, and diosgenin-treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). Diosgenin was administered p.o. at a dose of 40 mg/kg for 7 weeks. Some markers of oxidative stress including malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) were measured in cardiac tissue homogenate.
It was found out that diabetic group had an elevated MDA content (p Diosgenin could attenuate cardiac lipid peroxidation and improves non-enzymatic antioxidant defensive system in diabetic condition and it may be considered as a potential therapeutic agent to mitigate cardiac dysfunction in DM.