Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice

Scientificstudies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of V. vinifera juice (VVJ).
Light/dark box and the open field test were used to assess the anxiolytic potential of V. vinifera juice (VVJ). The juice was given orally by gavage at the dose of 4 and 8 mL/kg body weight. Diazepam (1 mg/kg i.p.) was used as the standard drug.
It was observed that the juice produced significant and dose dependent increase in the time spent in light cubicle (p In conclusion, the present study establishes the anxiolytic-like activity of VVJ in animal models of anxiety.