Enigmatic Inv(9): A Case Report on Rare Findings in Hematological Malignancies
Author(s):
Abstract:
Introduction
Inversion of chromosome 9 had been widely discussed among geneticists and evolutionary biologists because of its significant impact on various hereditary disorders and in the evolution of man. The role of such inversions in human disease evolution is an area hitherto unclear.Case Presentation
We present the case of a chronic myeloid leukemia (CML) patient who showed intermittent relapse on treatment, with a rare appearance of clones with dual inversion (9) breakpoints [inv(9)(p22q34); inv(9)(p11q21)]. We also present the first report of inv(9)(p11,q13) as the sole abnormality in a patient with chronic myeloproliferative disorder(CMPD). Both the patients registered in 2012 and were from Kerala, India.Conclusions
Both the cases discussed in our study have inv(9) as the sole abnormality and are found to confer a relatively poor prognosis.Keywords:
Language:
English
Published:
Iranian Red Crescent Medical Journal, Volume:18 Issue: 4, Apr 2016
Page:
16
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