The Association between GNB3 Gene Polymorphism and Endurance Sports: A Systematic Review and Meta-analysis

Although several studies have examined the association between gene polymorphism GNB3 and endurance exercise, the results are inconsistent. This systematic review and meta-analysis aims to summarize the relationship between GNB3 C825T polymorphism and endurance exercise performance.
We searched all studies published until January31, 2015 in databases PubMed, Google Scholar, Embase, Medline, Science Direct and SID. From ten studies of gene polymorphisms GNB3 and endurance exercise, we selected three studies for the meta-analysis.
No significant association existed between GNB3 polymorphism and endurance exercise in the T versus C allelic model (OR: 1.127; 95% CI: 0.877, 1.448; P=0.349),TT versus CC additive model (OR: 1.316; 95% CI: 0.900, 1.924; P=0.157), TT CT versus CC dominant model (OR: 1.098; 95% CI: 0.856, 1.408; P=0.464), and the TT versus CT CC recessive model (OR: 0.520; 95% CI: 0.520, 1.111; P=0.157).
The results showed that the GNB3 gene polymorphism was not associated with improving the performance of elite athletes in endurance sports. However, further studies would be needed in different ethnicities.