Evaluation of Early Hypothyroidism Effects on the Gonads Activity

This study was designed to evaluate specific effect of thyroid hormone on growth and development of reproductive organs in male rats, during one year period from 1994-1995 in the Dept of physiology M.S.U. of Tehran.
In this investigation the early hypothyroidism was induced with the use of PTU and the developmental changes in endocrine and nonendocrine organs (kidney and spleen) were studied.
The test group animals were those who recieved PTU, and the second group were the control animals.
During different periods after birth serum levels of testosterone hormones, testicular total protein synthesis, body weight and the ratio of spleen and kidney weights to total body weights were measured and compared with control groups.
In conclusion, in test group weight increase rate up to 60th day of life were less than the control and the differences were statistically significant (p