REPORT OF A FAMILY WITH PELGER-HUET ANOMALY
Author(s):
Abstract:
A 12-year-old boy was seen for abdominal pain and sent to the lab. For CBC. Even though CBC was normal in peripheral smear many of neutrophils (PMN) had only two lobes, with diagnosis of Pelger-Huet anomaly. CBC was performed on parents and three siblings which revealed the same type of anomaly in the mother and the other three children. The father was normal.
This anomaly was first described by Pelger who thought it was due to tuberculosis, later Huet recognized this phenomenon to be inherited as autosomal dominant. Basic anomaly here is limitation of lobing in PMN. In heterozygotes PMN are unsegmented and dumbel - shaped or bilobed and in homozygots the majority of PMN have round nuclei. Incidence is one in 6000 individuals. Except minimal impairment in migration, PMN function is normal.
Acquired Pelger-Huet-Iike change somtimes is seen in chronic infection of bowels, leukemia and non-Hodgkin lymphoma, some drug toxicity such as colchicine, and mycoplama pneumonia infection.
This anomaly was first described by Pelger who thought it was due to tuberculosis, later Huet recognized this phenomenon to be inherited as autosomal dominant. Basic anomaly here is limitation of lobing in PMN. In heterozygotes PMN are unsegmented and dumbel - shaped or bilobed and in homozygots the majority of PMN have round nuclei. Incidence is one in 6000 individuals. Except minimal impairment in migration, PMN function is normal.
Acquired Pelger-Huet-Iike change somtimes is seen in chronic infection of bowels, leukemia and non-Hodgkin lymphoma, some drug toxicity such as colchicine, and mycoplama pneumonia infection.
Keywords:
Language:
Persian
Published:
Razi Journal of Medical Sciences, Volume:4 Issue: 3, 1997
Pages:
62 to 65
magiran.com/p1570167
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!