THE EFFECT OF DIFFERENT PHARRMACOLOGICAL AGENTS ON NK/LAK KILLING & TUMOUR CELL LINES PROLIFERATION

The base of this study has been demonstrated the use of different drugs and dosages on different tumour cell lines and finally the effect of these drugs on natural killerllimphokine activated killer (NK/LAK) Killing. Tumour cells as target , mononeuclear cell activated with inter leukin-2(LAK) as effector, anti cancer drugs like tamoxifen , pentoxifylline , cycloheximide and cisplatin as stimulator or inhibitor of NK/LAK killing and colourimetric MT[ assay as evaluation agent. The different drugs with the similar dosages show stimulation or ingibition effect on NK/LAK killing. It is to be taken into concideration the possibility of metastasis of cancer is not unexpected. As the matter is important and needs more profound consideration , more studies and researches are currently being performed.