ALUMINIUM TOXICITY AND CHANGES IN SERUM PARAMETERS RELATED TO LIVER FUNCTION IN RATS

The effect of aluminium on serum parameters related to liver function was investigated over different period of times.
Serum lactate Dehydrogenase (LDH), Aspartate aminotrans­ferase (AST), Alanin aminotransferase (ALT) and total protein were chosen as indexes for liver function. Daily intraperitoneal administ­ration of 185 umoleslkg aluminium for 35 days elevated serum aluminium concentration from 10±0.5 to 668±81 f.lg/L.
Short term administration of 740 umoleslkg of aluminium daily for 10 days elevated LDH, AST, ALT and bilirubin concentrations by 27%, 18%, 62% and 60% respectively in comparison to controls. Daily administration of 35, 185 and 370 umoleslkg of aluminium for 60 days elevated serum levels of LDH (33%, 47% and 69%), AST (29%, 34% and 70%), ALT (31%, 39% and 77%) and bilirubin (26% , 36% and 41%) respectively.
Protein concentration was elevated significantly. Aluminium administration might disturb liver function by interferring with biochemical pathways.
The interference of aluminium with parameters related to liver function has been discussed here.