Evaluation of Prophylactic Injection of Two Doses of Tramadol on Heart Rate and Blood Pressure Changes Compared with Control Group after Laryngoscopy and Intubation

Laryngoscopy is an invasive technique which is associated with severe cardiovascular complications. This study compared the effects of two doses of tramadol hydrochloride (2mg/kg, 1mg/kg) on heart rate and blood pressure with control group after laryngoscopy and intubation in elective surgical patients.
In this clinical trial performed in 2015, 180 candidates in Kashani care center, Isfahan, Iran, were randomly divided to control (no drugs were used), tramadol 1mg/kg and tramadol 2mg/kg groups. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were recorded immediately before, after, and 1, 3 and 5 ,10 min after laryngoscopy. Data were analyzed using SPSS and ANOVA and Tukey post hoc tests.
Findings: There were significant differences in systolic, diastolic and mean arterial pressure between control group and two doses of tramadol (P Prescribing 2 mg/kg of tramadol causes more stable blood pressure and heart rate compared with control group.