Study on the effects of Benzo(a)pyrene exposure on renal tissues in Common Carp, Cyprinus carpio

Benzo(a)pyrene (BaP) is an important compound of polycyclic aromatic hydrocarbons (PAHs) that is carcinogenic and very toxic. In this research, 45 pieces of common carp, Cyprinus carpio were divided to 2 BaP treated groups (those received 50 and 100 mg per Kg body weight) and a control group in 3 replicates for each group. BaP were injected intraperitoneally to evaluate its direct effects. Renal histological responses were examined at 24, 72 and 168 hours after exposing to toxicant. After 24 hours, more histopathological lesions were observed in 100 mg/Kg BW when compared with 50 mg/Kg and control groups. More lesions were observed in both 50 and 100 mg/Kg treatments in 72 up to 168 hours samples. Hypertrophy and hyperplasia of epithelial cells in Bowman's capsule, glomerular capillary aneurysm, epithelial lifting, tubular cell necrosis, and blood cell in Bowman's capsule were the most frequent observed alterations. There were significant differences between renal tubule diameters in different treatments and sampling times (P