Socket preservation using freeze‐dried bone allograft with and without plasma rich in growth factors in dogs
Author(s):
Abstract:
Background
Plasma rich in growth factors (PRGF) and freeze‑dried bone allograft (FDBA) are shown to promote bone healing. This study was aimed to histologically and histomorphometrically investigate the effect of combined use of PRGF and FDBA on bone formation, and compare it to FDBA alone and control group.Materials And Methods
The distal roots of the lower premolars were extracted bilaterally in four female dogs. Sockets were randomly divided into FDBA PRGF, FDBA, and control groups.Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 4 weeks. Sockets were assessed histologically and histomorphometrically. Data were analyzed by KruskalWallis test followed by MannWhitney U‑tests utilizing the SPSS software version 20. P
Results
While the difference in density of fibrous tissue in three groups was not statistically significant (P = 0.343), the bone density in grafted groups was significantly higher than the control group (P = 0.021). The least decrease in all socket dimensions was observed in the FDBA group. However, these differences were only significant in coronal portion at week 4. Regarding socket dimensions and bone density, the difference between FDBA and FDBA㴑 groups was not significant in middle and apical portions.Conclusion
The superiority of PRGFᐰ overFDBA in socket preservation cannot be concluded from this experiment.Keywords:
Language:
English
Published:
Dental Research Journal, Volume:13 Issue: 5, Sep 2016
Page:
7
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