Poorly Differentiated Neuroendocrine Carcinoma of Stomach: A Case Report

Neuroendocrine carcinoma (NEC) of stomach is a rare and highly malignant tumor. It rarely occurs in the gastrointestinal (GI) tract especially in stomach. In this report, an 81-year-old male is presented with chief complaint of epigastric pain and early satiety. Endoscopic examination of the upper GI tract revealed an ulcerative mass measuring 3x4x4 cm in body of stomach, and a biopsy was taken. Accordingly, poorly differentiated neuroendocrine carcinoma was observed on microscopic examinations. On immunohistochemical staining, neuroendocrine carcinoma was confirmed. After six cycles of chemotherapy the primary tumor size declined and also improvement of hepatic metastasis was observed. Due to acceptable responses of these tumors to therapy, clinical and morphological evaluations along with specific staining are necessary.