Evaluation of the Preventive Effect of Midodrine Administration on Vasoplegia during Cardiac Surgery, Compared with the Control Group

Cardiac vasoplegic syndrome is vasodilatory shock that occurs in half of the patients after cardiopulmonary bypass surgery and increases mortality and morbidity rates in these patients. The aim of this study was to evaluate the preventive effect of midodrine administration on vasoplegia during cardiac surgery.
The study included 71 patients undergone cardiac surgery. The patients were randomly divided into two groups and the intervention group received a tablet of 5 mg midodrine and control group received placebo one hour before the surgery. Vital signs in both groups during different levels of surgery were studied. The data were compared using t, chi-square and Mann-Whitney tests.
Findings: According to mean differences in patients’ vital signs in both groups before induction of anesthesia, we found that the mean difference in diastolic blood pressure after anesthesia (P = 0.004) and after pump (P = 0.009), dropped in the control group for 0.49 and 5.5 mmHg, respectively; while in the intervention group it was stable. Administered ephedrine was lower in intervention group (20.71 mg) than the control group (41.56 mg) (P = 0.001).
This study showed that systolic and diastolic blood pressures in patients receiving midodrine were greater than the control group during cardiac surgery. Midodrine stabilizes vital signs and reduces the risk of cardiac vasoplegic syndrome.