Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer

Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer.
To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer.
Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease (PUD, n=25), and gastric cancer (GC, n=27) according to their endoscopic and histopathological examinations. Helicobacter pylori infection was diagnosed by rapid urease test and histopathology. The number of peripheral blood CD4࠽맸娱㽿鎭 and CD14ᲰDR- MDSCs were determined in all patients, by flow cytometry. The number of FoxP3 regulatory T cells was also determined by immunohistochemistry (IHC).
The percentage of peripheral blood Treg cells in both PUD )0.81 ± 0.39, p Both Tregs and MDSCs showed higher frequencies in PUD and GC. These results suggest that immune-modulation by the Tregs and MDSCs may play a role in the pathogenesis of PUD and GC.