The prevalence of hypogonadism in patients with thalassemia major in Iran - a systematic review and meta-analysis study
Author(s):
Abstract:
Background And Aims
Hypogonadism is one of the most common endocrine complications in patients with thalassemia major. A simple review of studies show different hypogonadism prevalence and has been reported between 31.3-88% in Iranian patients with thalassemia major. So, this meta-analysis study was conducted to determine the hypogonadism prevalence in Iranian patients with thalassemia major.Methods
This study was conducted based on PRISMA checklist for systematic review and meta-analysis studies. A comprehensive search by two researchers was conducted according to MESH keywords in databases such as Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Science Direct, Cochrane, Embase, Springer, Online Library Wiley and also search engine Google Scholar. Then, all articles were examined without any time limited until October 2015. Data were analyzed using random effects model and Stata ver. 11.1 software.Results
Sixteen studies involving 2938 patients with average age of 17.34 were identified to analyze in the meta-analysis. Hypogonadism prevalence in patients with thalassemia major in Iran has been estimated 42.3% (CI 95%: 30.7-53.8). Minimum and maximum prevalence in Iran were related to the center (41%) and east (45%), respectively. Hypogonadism prevalence in male and female patients was 49% and 45.2%, respectively. There was no significant relationship between hypogonadism prevalence and year of the study and sample size.Conclusion
The prevalence of hypogonadism in Iranian patients with thalassemia major is high and it is needed to perform a continuous and regular plan and follow up for these patients.Keywords:
Prevalence , Hypogonadism , Thalassemia major , Meta , analysis , Iran
Language:
Persian
Published:
Journal of Shahrekord University of Medical Sciences, Volume:18 Issue: 5, 2016
Pages:
140 to 151
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