Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats
Author(s):
Abstract:
Background
Previous studies on the medial prefrontal cortex (mPFC) has shown that this area plays an important role in addiction behavior. Other studies also indicated that exercise decreases use of morphine..Objectives
The aim of this study was to evaluate the effects of short-term exercise on trends for use of morphine with an intact mPFC and lesion of that area..Methods
50 rats randomly were selected and divided into 5 groups. 1-exercise. 2- Morphine Lesion. 3- Morphine Exercise Lesion. 4- Morphine. 5- Morphine and Exercise. All groups received morphine for 9 days except exercise group. On the 10th day, the symptoms of addiction were evaluated. To determine the effects of exercise, a treadmill apparatus was used for exercising..Results
Our results indicated that exercise with intact mPFC area significantly decreased the tendency of using morphine which is verified by changes in symptoms (P Conclusions
It seems that a lesion of mPFC area significantly reduced the effect of short-term exercise on the usage pattern of morphine..Keywords:
Language:
English
Published:
Asian Journal of Sports Medicine, Volume:7 Issue: 4, Dec 2016
Page:
7
https://www.magiran.com/p1637408
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