In vitro and in vivo antioxidant potentials of Alchornea floribunda leaf extract, fractions and isolated bioactive compounds
Author(s):
Abstract:
Objective
Alchornea floribunda leaves are widely used in ethnomedicine for the management of immuno-inflammatory disorders. We investigated the in vivo and in vitro antioxidant activity of the leaf extract, fractions and isolated compounds of A. floribunda.Materials And Methods
The ethyl acetate fraction of the methanol leaf extract was subjected to several chromatographic separations to isolate compounds 1-4. The structures of the isolated compounds were elucidated by a combination of 1D and 2D NMR and mass spectrometry. Oxidative stress was induced with carbon tetrachloride (CCl4). Further analysis on the isolated phenolic compounds were done using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and hydrogen peroxide scavenging activity tests.Results
The ethyl acetate fraction at 200 mg/kg produced significant (pConclusion
The medicinal uses of A. floribunda may be due to the antioxidant activities of its phenolic compounds. Keywords:
Language:
English
Published:
Avicenna Journal of Phytomedicine, Volume:7 Issue: 1, Jan 2017
Pages:
80 to 92
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