Comparison of Assessing the Success of Cell Transplantation in Experimental Parkinson by Measuring Homocysteine with Behavioral Symptoms
Author(s):
Abstract:
Introduction
Parkinson is a brains degenerative disease. Evidence shows that the levels of homocysteine increases in the Parkinson's disease. In this study, the success of cell transplantation was evaluated by comparison between serum homocysteine levels and behavioral symptoms in experimentally Parkinson's induced by 6-hydroxy dopamine (6- OHDA).Methods
This experimental study was conducted in 2014 on male Wistar rats. The rats initially were Parkinsonism through stereotaxic 6- OHDA microinjection into right middle frontal areas of right hemisphere. Parkinson's was confirmed by apomorphine-induced rotation test. Then the rats treated with stem cell transplantation and the effect of treatment was assessed again. The total level of homocysteine was measured before, six weeks after 6- HDOA injection and ten weeks after cell transplantation. Data were analyzed using paired t-tests, ANOVA and Tukey test.Results
The total level of homocysteine didnt change significantly in rats with higher number of rotations. But ten weeks after cell transplantation, the level of homocysteine decreased significantly.Conclusion
Considering the direct correlation between the severity of rotational behavior and the degree of lesion in the substantia nigra (SN), our data indicate that higher tHcy values can predict higher SN dopaminergic neurodegeneration.Keywords:
Language:
Persian
Published:
Journal of Knowledge & Health, Volume:11 Issue: 4, 2017
Pages:
48 to 55
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