The Efficacy of Mentha longifolia in the Treatment of Patients With Postprandial Distress Syndrome: A Double-Blind, Randomized Clinical Trial

Functional dyspepsia (FD) is a common gastrointestinal disease that has various treatments, including medicinal plants.
The current study aimed to investigate the effect of Mentha longifolia on relieving the symptoms and improving the quality of life (QOL) in patients with functional dyspepsia from the subgroup of postprandial distress syndrome (PDS).
Patients and This randomized, double-blind, placebo-controlled trial was conducted in a gastroenterology clinic affiliated with Isfahan University of Medical Sciences. One hundred patients diagnosed with PDS according to the ROME III criteria were assigned to two groups: the M. longifolia capsules (three times daily for four weeks) group and the placebo group. Tools for gathering data were the FD severity scale and QOL (Persian version of the SF-36 questionnaire). Assessments of FD symptoms were obtained at baseline and also at the end of weeks 2, 4, and 12. QOL was evaluated at baseline and at the end of week 12.
At the end of treatment period, the M. longifolia group reported a more significant improvement in the mean severity scales of FD symptoms than the placebo group (P This study showed the efficacy of M. longifolia in relieving PDS symptoms and improving the QOL of patients with PDS.