Corneal thickness measurements with Scheimpflug and slit scanning imaging techniques in keratoconus

To determine the repeatability of corneal thickness measurements with Scheimpflug (Pentacam) and slit scanning (Orbscan) imaging techniques in different grades of keratoconus.
This study was conducted as a cross-sectional research. Imaging with Orbscan and Pentacam was performed on patients with different grades of keratoconus. With each device, 3 measurements were taken at 10 min intervals. Repeatability indices in different grades of keratoconus were calculated for each device.
Seventy-four eyes of 42 keratoconus patients were enrolled. Repeatability index (RI) of central corneal thickness (CCT) measurements in keratoconus grade 1, 2, and 3, were 12.8, 9.9, and 24.2 with Pentacam, and 23.6, 26.3, and 59.3 with Orbscan, respectively. For the thinnest point, these figures were 9.6, 8.0, and 35.7 with Pentacam and 19.5, 16.6, and 26.8 with Orbscan, respectively. The 95% limit of agreement (LOA) between Pentacam and Orbscan in measuring CCT and thinnest point in grade 1 were
25.5e47.7 mic and
33.3e32.8 mic, respectively. These results for grade 2 were
9.8e50.6 mic and
26.2 43.7 mic, respectively. In grade 3, 95% LoA were
20e64.6 mic and
31.4e60.5 mic, respectively.
The results of this study showed that although repeated measurements of the CCT with Orbscan and Pentacam are strongly correlated, repeatability values of CCT measurements significantly decrease at more advanced grades of keratoconus. In all keratoconus grades, repeatability of CCT measurements was better with Pentacam than Orbscan. These findings indicate that corneal thickness readings have less validity in patients with advanced keratoconus.