Effects of Inactive Vitamin D on Persistent Secondary Hyperparathyroidism in Patients on Hemodialysis

Secondary Hyperparathyroidism (sHPT) is an important feature of chronic renal failure and contributes to the development of renal osteodystrophy. This study was carried out to assess 25(OH)D status and its effect on sHPT in patients on hemodialysis (HD).
A prospective experimental trial of 180 HD patients (F: 81, M: 99, age > 14year) participated in the study. At base line, levels of 25(OH)D, intact Parathyroid Hormone (iPTH), Calcium (Ca), Phosphorous (P), Alkaline phosphatase (Alk p), and albumin of serum were measured. Patients with 25(OH)D deficiency ( 300 pg/mL.
Serum 25(OH)D levels were deficient in 87.8% (n: 158) of subjects, and normal in 12.2% (n: 22). The prevalence of sHPT, according to 25(OH)D levels, was 71.5% (n: 113)( These findings showed that 25(OH)D insufficiency was highly prevalent in HD cases and higher amount of 25(OH)D levels prevent sHPT.