Association between HbA1C Level and Lower Extremity Amputation in Patients with Diabetic Foot

Introduction & The lower limb amputations are common musculoskeletal complications of diabetes mellitus and determination of the contributing factors is important for preventive programs.
In this observational descriptive-comparative cross-sectional study, 100 consecutive patients with diabetic foot attending to Shohada-e-Tajrish Hospital in 2014 and 2015 were enrolled and the association between HbA1C level and lower extremity amputation in them was determined.
The results in this study demonstrated that mean hemoglobin A1C levels were 8.5 ± 1.3 and 7.9 ± 1.1 g/dl in those with and without amputation, respectively showing statistically significant difference (P = 0.016). The hemoglobin A1C level was not related to location of limb amputation (P > 0.05).
Totally, it may be concluded that there is significant association between HbA1C level and lower extremity amputation in patients with diabetic foot.