The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial

Abstract:
Background
This study was designed to investigate the effect of intravenous magnesium sulfate on hemodynamic changes induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.
Methods
A randomized, placebo controlled study was performed on 52 ASA class I or II aged 20-70 years patients undergoing laparoscopic cholecystectomy with pneumoperitoneum with carbon dioxide. Before induction, Magnesium group received 50 mcg.kg-1 magnesium sulfate, within 10 minutes, in 100 ml of normal saline and control group received 100 ml normal saline. Hemodynamic variables were recorded before induction, before the infusion of magnesium sulfate, during intubation, during pneumoperitoneum and finally during extubation, every 10 minutes. Postoperative pain and other complications were recorded in post anesthesia care unit (PACU) also.
Results
Variations in heart rate and mean arterial pressure between the two groups during pneumoperitoneum were not significantly different (P>0.05). Propofol consumption in the magnesium group compared with the control group was significantly decreased (P
Conclusion
Magnesium sulfate reduces the amount of anesthetic drug (propofol), TNG and intraoperative blood pressure, during pneumoperitoneum induced by laparoscopy. The postoperative pain of laparoscopy and anesthesia side effects such as nausea, vomiting and shivering were blunted, with bolus administration of magnesium sulfate before induction of anesthesia.
Language:
English
Published:
Archives of Anesthesiology and Critical Care, Volume:3 Issue: 2, Spring 2017
Pages:
313 to 318
https://www.magiran.com/p1692743  
سامانه نویسندگان
  • Zamani، Mohammad Mahdi
    Author (2)
    Zamani, Mohammad Mahdi
    Assistant Professor Department of Anesthesiology & Critical Care & Pain Medicine, Iran University Of Medical Sciences, تهران, Iran
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