Effect of L-Arginine supplementation on nAchR response in skeletal muscles to exhaustive acute exercise in old rats

The purpose of this study was to investigate the effect of L-arginine supplementation on the nAchR response in hind limb of old male rats after exhaustive acute exercise. For this purpose, 32 Wistar rats (age: 22 months, weight: 380±20gr) were selected. After one week of familiarization with laboratory environment, they were randomly divided into four groups consisted of:1) L-arginine supplement with one session of exhaustive endurance exercise, 2) L-arginine supplement 3) exercise and 4) control group. For the supplementation groups, they consumed water containing 2.5% L-arginine for two weeks. In the exercise day, the training groups performed an exhaustive running with 30 meter per minute speed and 5-degree incline, equivalent to approximately 75-80% of their VO2max. Immediately and four hours after exercise they anesthesia and sampling was performed from EDL and Soleus muscles. Then, for statistical analysis of the datas, the one-way ANOVA was used. data of this study illustrate that nAchR level in L-arginine supplement, significantly was higher than control group in EDL and Soleus muscles (p