The effect of Fe2Nio4 and Fe4Nio4Zn nanoparticles on hepatic, renal and spleen tissues in male wistar rat

Nanoparticles in a wide range of consumer products (cosmetics, health, industrial, ...) is used. The aim of this study is to evaluate the effect of the nanoparticle Fe2NiO4 and Fe4NiO4Zn on the Hepatic, Renal and Spleen Tissues.
This study of experimental was conducted on 40 male Wistar rats. The average weight was between 200-250g and divided into 5 groups. Group I: control group received 0.5ml saline. Respectively it was injected 0.5ml from second to fifth group with concentration 100 and 200 ppm of Fe4Nio4Zn and Fe2Nio4 nanoparticles. These injections were performed for 7 consecutive days with intraperitoneally injection.
Results of H and E showed that Fe4NiO4Zn nanoparticles (200nm) had effect on the hepatic tissue and caused to damage tissues. Also, upper doze of (200nm) damaged to spleen tissue. Fe2NiO4 nanoparticle with doze (200nm) damaged the renal tissue, but, Fe2NiO4 nanoparticle with doze (100nm) had not no effect on hepatic, renal, and spleen tissues. The results of iron stain in the current study showed that iron has deposited on the spleen tissue in all of groups, but this iron sediment in the spleen in Fe4NiO4Zn treatment group (100, 200nm) was more compared with the control group (groups that contain zinc nanoparticles).
Both of Fe2NiO4 and Fe4NiO4Zn nanoparticles damage on Hepatic, renal and spleen tissues, but, damage in both of them was more in an upper doze, and iron stain showed that Fe4NiO4Zn caused more damage on spleen.