Evaluation of cardiac ejection fraction and fractional shortening following oral administration of cisapride in dogs

Cispride drug as a procinetic drug in digestive system, causes prolongation of the QT interval by electrophysiologic changes in the ion channel that is responsible for the rapid component of the delayed rectifier current for potassium (IKr). This drug is metabolized by cytochrome P450. However, serious cardiac arrhythmias have been reported in patients taking cisapride like ventricular tachycardia and hypokinetic heart. The goal of this issue is to measure the ventricular size by evaluating of ejection fraction and fractional shortening following oral administration of cisapride.In this appraisal, six domestic dogs were randomly selected. Then all of them were issued on echocardiographic changes in two times as before administration and after administration of 1 mg/kg cisapride for three times day. Two- dimensional B-mode and M-mode pictures were analysed.The results confirmed that by oral administration of cisapride ventricular function became impaired and the Frank-Starling law of the heart was note operative. The side effects were reduction of heart rate, declining of ejection fraction and fractional shortening which resulted Decreased cardiac contractility heart.