Study of Chromosomal Abnormalities in Couples with Recurrent Miscarriage in Zahedan, Iran

Recurrent miscarriage (RM) is defined as the presence of two or more spontaneous abortions. It has been estimated that 1% to 3% of couples experience RM. Furthermore, RM is considered as a multifactorial disease and genetic disorders are one of the suggested issues. In this study, 30 couples with RM were evaluated for their karyotypes, for the first time in Sistan and Baluchestan province.
In this study, 60 individuals (30 couples) with a history of recurrent miscarriage were recruited for cytogenetic evaluation through karyotyping of peripheral blood. All the participants in this study took part in immunologic, hematologic, and anatomic evaluations and no abnormality was found.
Among all male and female subjects of this study, only 2 females (6.7%) showed chromosomal aberration: mos45, X(3)/46XX(47) and 46, XX, and inv (8)(p12q21). Both of these females had no children with a record of 3 miscarriages. These females and their partners had no history of miscarriage in their family.
The number of chromosomal abnormalities found in this Study (6.7%) was less than other studies conducted in Iran, including the city of Mashad, Yazd, Tehran, and Ahvaz. This might be because of the low number of participants taking part in this investigation. Therefore, it is a necessity to perform furhter evaluations in this regard.