Comparing the Outcomes and Side Effects of Administration of a Single Preoperative Dose of Vaginal Misoprostol With Intraoperative Oxytocin Infusion in Blood Loss During Abdominal Myomectomy

This study aimed to compare the effectiveness of a single preoperative dose of misoprostol with intraoperative oxytocin infusion in abdominal myomectomies.
Patients undergoing abdominal myomectomies were divided into 2 groups. An hour before the operation, women in the misoprostol group (n = 35) received a single dose of vaginal misoprostol (400 μg); those in the oxytocin group (n = 35) received oxytocin (intravenous infusion of normal saline solution [30 units in 1000 mL] during myomectomy).
Blood loss, operation time, and need for blood transfusion were significantly reduced in the group administered with vaginal misoprostol. No difference was observed between patients in term of the period of hospitalization and complications. The results of oxytocin in abdominal myomectomy showed no significant difference.
Administration of a single preoperative dose of misoprostol could be a simple and reliable method for reducing intraoperative blood loss and need for postoperative blood transfusion in abdominal myomectomies.