Drug Delivery of Nanofibers Based on Biodegradable Synthetic Polymer Blends: A Review

Taking a drug/medicine by conventional methods (digestive and indigestive) by patients leads to the release of high dosage of drug in their body. The concentration of drug decreases after a few hours and the patients need to take the next dose again, and such cycle continues. By development of nanoscience and its technology, some new controlled drug delivery systems have been proposed instead. These new systems are expected to improve patient's convenience and compliance, because they are made of biocompatible and biodegradable polymers in controlling drug delivery in the body. Biodegradable polymers can be classified as synthetic and natural polymers with their own specific features. To control the delivery of the drugs, a blend of polymers can be used. In this paper, the effect of blended synthetic biodegradable polymers on controlled drug delivery by electrospun nanofiber is reviewed.