The Effect of Saffron on Semen Analysis in Infertile Men with Clinical Varicocele After Varicocelectomy
Abstract:
Background
Infertility affects 15% of couples and varicocele is the most common cause of male infertility. Oxidative stress is recommended as a possible mechanism of infertility. Crocus sativus (saffron) has been recognized as having antioxidative properties and is presumed to improve sperm parameters.
Objectives
The present study aims to evaluate the effect of saffron on semen analysis of infertile men with clinical varicocele after varicocelectomy.
Methods
In this randomized clinical trial, 48 infertile men candidates for varicocelectomy were randomly assigned to receive 60 mg edible saffron capsules once every other day (n = 27) or a similar regimen of placebo (n = 21) for 6 months. The two groups were compared for changes in semen parameters.
Results
There was no significant difference between groups in semen parameters before treatment as well as in semen volume, morphology, and sperm count post-treatment, but motility was significantly higher in the saffron group (30.00 ± 14.46 vs. 21.71 ± 11.45; P = 0.03). There was one (3.7%) complication in the saffron group.
Conclusions
Our results showed that except improving sperm motility, saffron has no effect on other semen parameters in infertile men with clinical varicocele after varicocelectomy.
Language:
English
Published:
Nephro-Urology Monthly, Volume:9 Issue:5, 2017
Page:
6
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