Interferon Gamma Polymorphism and Expression Relationship with Severity of Coronary Artery Disease in Golestan, Iran

The Coronary artery disease (CAD) occurs as a result of atherosclerotic plaque formation. The interferon gamma (IFNγ) as a multifunctional cytokine is involved in inflammatory processes in atherosclerosis.
We investigated the relationship between IFNγ (ᏼ) SNP with CAD. Moreover, we compared IFNγ mRNA expression in CAD patients and healthy controls.
Patients and This case-control study with randomized sampling included 300 patients with CAD and 301 normal controls. The SSP-PCR method was used for genotyping IFNγ (ᏼ) gene polymorphism. Quantitative Real-Time PCR was performed to measure IFNγ mRNA expression. All data was analyzed by GraphPad software. The chi-square and ordinal logistic regression tests were used to analyze differences in genotype frequencies.
In this study, there was a significant association between male genders with CAD (P IFNγ gene functional polymorphism can be associated with incidence and severity of CAD. IFNγ mRNA level was also increased in CAD patients in comparison with controls. Therefore, IFNγ may play a role in predisposition to CAD.