Eco-friendly Stability-Indicating Potentiometric Method for the Determination of Ropinirole Hydrochloride
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
A new fabricated ion selective electrode was described for the determination ropinirole HCl by direct potentiometry in pure drug substance and in pharmaceutical formulation. The proposed sensor was fabricated using ammonium reineckate (AR) as a cationic exchanger and 2-nitrophenyl octylether as a plasticizer in a polymeric matrix of polyvinyl chloride (PVC). Nernstian response of 55.1 mV/decade was obtained by the proposed sensor over a wide RP concentration range (105 to 1×102 mol/L) in the pH range of 37. The proposed sensor was stable for two weeks without any change in sensitivity. The proposed electrode shows good selectivity for the analysis of RP in the presence of up to 30% of its induced alkaline degradation product and in the presence of common inorganic and organic species commonly present in pharmaceutical dosage form. Statistical comparison between the results obtained by the proposed sensor for the analysis of ropinirole HCl in dosage form and the reported one shows no significant difference with respect to accuracy and precision.
Keywords:
Language:
English
Published:
Analytical & Bioanalytical Electrochemistry, Volume:9 Issue: 8, Dec 2017
Pages:
1044 to 1056
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